反応 #674320

反応方程式

A1

3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

2,4-dichloro-1,3,5-triazine

3-aminobenzenesulfonamide

→

desired product A2

収率 35.0%

3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenesulfonamide

収率 35.0%

反応条件

後処理

1. 1
   その他A2 was prepared
2. 2
   その他The crude product was purified by flash chromatography on silica gel (cHex/EtOAc=20:1 to 1:20)

実験手順

A2 was prepared following the general procedure reported for A1 using 2,4-dichloro-1,3,5-triazine and 3-aminobenzenesulfonamide as reacting agents. The crude product was purified by flash chromatography on silica gel (cHex/EtOAc=20:1 to 1:20) to yield the desired product A2 as a white solid (35%). 1H NMR (400 MHz, d6-DMSO, 300K) δ 7.41 (s, 2H), 7.59 (m, 2H), 7.85 (d, J=6.9 Hz, 1H), 8.21 (br.s, 1H), 8.69 (s, 1H), 11.02 (s, 1H). MS (ES) C9H8ClN5O2S requires: 285. found: 286 (M+H)+.

出典