反応 #674287

ord-9fb1ff1cb2d94f1da5086a474289cc48

反応方程式

[Ca+2].[Cl-].[Cl-]
calcium chloride
O=P([O-])([O-])O
hydrogen phosphate
[Na+].[OH-]
NaOH
O=P([O-])([O-])[O-].O=P([O-])([O-])[O-].[Ca+2].[Ca+2].[Ca+2]
Calcium Phosphate

溶媒

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他CaP NPs
  2. 2
    その他were obtained by filtration of the suspension through a 0.22 μm
  3. 3
    ろ過filter
  4. 4
    その他CaP NPs
  5. 5
    その他were stored at 4° C. before use
  6. 6
    その他CaP/ZOL-NPs complexes (CaPZ NPs) were prepared

実験手順

An aqueous solution of calcium chloride (18 mM) was added, dropwise and under magnetic stirring, to an aqueous solution on dibasic hydrogen phosphate (10.8 mM). The pH of both solutions was adjusted beforehand to 9.5 with NaOH. CaP NPs were obtained by filtration of the suspension through a 0.22 μm filter. CaP NPs were stored at 4° C. before use. CaP/ZOL-NPs complexes (CaPZ NPs) were prepared by mixing a CaP NPs dispersion with an aqueous solution of (50 mg/ml of ZOL in phosphate buffer at pH 9.5), at a volume ratio of 50:1.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09226897B2uspto-grants-2016_01