反応 #67428

反応方程式

1-(benzo[d][1,3]dioxol-5-yl)-cyclopropanecarboxylic acid

CH2Cl2

thionyl chloride

→

1-Benzo[1,3]dioxol-5-yl-cyclopropanecarbonyl chloride

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   その他(2-3 h)
2. 2
   その他The excess thionyl chloride was removed under vacuum
3. 3
   workup.DISSOLUTIONthe resulting residue dissolved in CH2Cl2 (3 mL)

実験手順

To an oven-dried round bottom flask containing 1-(benzo[d][1,3]dioxol-5-yl)-cyclopropanecarboxylic acid (A-8) (618 mg, 3.0 mmol) and CH2Cl2 (3 mL) was added thionyl chloride (1.07 g, 9.0 mmol) and N,N-dimethylformamide (0.1 mL). The reaction mixture was stirred at ambient temperature under an Ar atmosphere until the gas evolution ceased (2-3 h). The excess thionyl chloride was removed under vacuum and the resulting residue dissolved in CH2Cl2 (3 mL). The mixture was used without further manipulation.

出典