反応 #67390

ord-ee649061a5d1459fbcf89e3caa807012

反応方程式

CC(CN1c2ccccc2Sc2ccccc21)N(C)C.Cl
promethazine HCl
C=CN1CCCC1=O
polyvinylpyrrolidone K 90
O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
C/C=C/C=C/C(=O)O
sorbic acid
OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O
sucrose
→
CC(CN1c2ccccc2Sc2ccccc21)N(C)C
Promethazine

反応物

—
amber glass
CC(CN1c2ccccc2Sc2ccccc21)N(C)C.Cl
promethazine HCl
C=CN1CCCC1=O
polyvinylpyrrolidone K 90
O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
C/C=C/C=C/C(=O)O
sorbic acid
OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O
sucrose

試薬

なし

溶媒

O
water

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

22.6 g of promethazine HCl, 25.0 g of polyvinylpyrrolidone K 90 prepared as in Example 8, 5.0 g of citric acid, 2.0 g of sorbic acid and 60.0 g of sucrose were dissolved in 975.0 g of demineralized water at 50° C., and the solution was cooled to room temperature and dispensed into 50 ml amber glass bottles.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08524827B2uspto-grants-2013_09