反応 #673739

反応方程式

CH2Cl2 CH3OH

4-chloro-2-methyl-phenyl isothiocyanate

2-amino-4-methyloxazole

→

title compound

1-(4-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea

溶媒

CH3CN

反応条件

後処理

1. 1
   その他Prepared
2. 2
   その他to give 4.5 g of crude title compound

実験手順

Prepared using Method A from 4.04 g (22 mmol) of 4-chloro-2-methyl-phenyl isothiocyanate and 2.16 g (22 mmol) of 2-amino-4-methyloxazole to give 4.5 g of crude title compound. Pure title compound was obtained by flash chromatography (silica Merck 60, CH2Cl2—CH3OH, 19:1) and crystallization from CH3CN to give 2.12 g of the title compound as a yellow solid (72.5% yield, m.p. 214° C. with decomposition).

出典