反応 #67282

反応方程式

1-(5-bromo-3-fluoro-2-hydroxyphenyl)ethanone

(R)-glycidyltosylate

K2CO3

→

title compound

収率 39.9%

1-(5-BROMO-3-FLUORO-2-[(2R)-OXIRAN-2-YLMETHOXY]PHENYL) ETHANONE

収率 39.9%

溶媒

DMF

反応条件

後処理

1. 1
   その他Preparation
2. 2
   洗浄The combined organic phases were washed with LiCl (5%), HCl (1 N)

実験手順

Preparation according to Preparation 1 using 1-(5-bromo-3-fluoro-2-hydroxyphenyl)ethanone (16.8 g, 72 mmol), (R)-glycidyltosylate (18.1 g, 79 mmol), K2CO3 (15.0 g, 108 mmol) and DMF (60 ml). The combined organic phases were washed with LiCl (5%), HCl (1 N). Flash column chromatography (isooctane/EtOAc) yielded the title compound (8.3 g). MS m/z (rel. intensity, 70 eV) 290 (M+, 9), 288 (M+, 9), 217 (bp), 81 (47), 57 (46).

出典