反応 #67265

反応方程式

5-bromo-2-hydroxybenzaldehyde

(S)-glycidyltosylate

K2CO3

DMF

→

crude title compound

収率 107.6%

5-BROMO-2-[(2S)-OXIRAN-2-YLMETHOXY]BENZALDEHYDE

収率 107.6%

溶媒

Water

反応条件

後処理

1. 1
   その他Preparation
2. 2
   抽出the solution was extracted with EtOAc (3×100 ml)
3. 3
   洗浄The combined organic phases were washed with LiCl (5%, 100 ml), HCl (1 N, 100 ml), brine
4. 4
   その他were dried
5. 5
   濃縮concentrated

実験手順

Preparation according to Preparation 1 using 5-bromo-2-hydroxybenzaldehyde (6 g, 30 mmol), (S)-glycidyltosylate (8.2 g, 36 mmol), K2CO3 (4.9 g, 36 mmol) and DMF (12 ml). Water (100 ml) was added and the solution was extracted with EtOAc (3×100 ml). The combined organic phases were washed with LiCl (5%, 100 ml), HCl (1 N, 100 ml), brine, were dried and concentrated to give the crude title compound (8.3 g). MS m/z (rel. intensity, 70 eV) 257 (M+, 38), 256 (M+, 39), 200 (bp), 199 (87), 57 (88).

出典