反応 #67258

反応方程式

3-fluoropropan-1-amine HCl-salt

[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate

3-fluoropropan-1-amine

→

3-FLUORO-N-{[7-(METHYLSULFONYL)-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHYL}PROPAN-1-AMINE

反応条件

実験手順

3-fluoropropan-1-amine HCl-salt (0.178 g, 1.52 mmol) was basified on a SCX-3 ion exchange column (TEA/MeOH). [7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate (0.020 g, 0.0561 mmol) and 3-fluoropropan-1-amine (0.15 M in MeOH/TEA:4/1, 5 ml) was heated under microwave radiation at 120° C. for 1 h 20 min. MS m/z (rel. intensity, 70 eV) 301 (M+, 3), 131 (8), 91 (9), 90 (bp), 86 (18), 70 (18).

出典