反応 #67186

反応方程式

hydrochloric acid

[7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

N-propylpropan-1-amine

→

N-{[7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}-N-PROPYLPROPAN-1-AMINE

溶媒

ACN

反応条件

後処理

1. 1
   その他Preparation
2. 2
   その他crystallized from MeOH/Et2O

実験手順

Preparation according to Example 14 using [7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.175 g, 0.44 mmol), N-propylpropan-1-amine (1 ml) and ACN (3 ml). Yield: 0.11 g, 77%. The amine was converted to the hydrochloric acid salt and crystallized from MeOH/Et2O. M.p. 182° C. MS m/z (rel. intensity, 70 eV) 327 (M+, 1) 114 (100), 298 (17), 115 (8), 86 (6).

出典