反応 #6714

反応方程式

Benzyl chloride

sodium hydroxide

NaOH

hexaethylene glycol

→

16

Hexaethylene glycol monobenzyl ether

溶媒

brine

water

反応条件

後処理

1. 1
   温度the reaction mixture was heated
2. 2
   温度The reaction mixture was then cooled
3. 3
   抽出extracted with methylene chloride (200 ml×2)
4. 4
   洗浄The combined organic layers were washed with brine once
5. 5
   乾燥dried over Na2SO4
6. 6
   ろ過filtered
7. 7
   濃縮concentrated in vacuo to a dark brown oil
8. 8
   その他The crude product mixture was purified via flash chromatography (silica gel, gradient elution: ethyl acetate to 9/1 ethyl acetate/methanol)

実験手順

An aqueous sodium hydroxide solution prepared by dissolving 3.99 g (100 mmol) NaOH in 4 ml water was added slowly to non-polydispersed hexaethylene glycol (28.175 g, 25 ml, 100 mmol). Benzyl chloride (3.9 g, 30.8 mmol, 3.54 ml) was added and the reaction mixture was heated with stirring to 100° C. for 18 hours. The reaction mixture was then cooled, diluted with brine (250 ml) and extracted with methylene chloride (200 ml×2). The combined organic layers were washed with brine once, dried over Na2SO4, filtered and concentrated in vacuo to a dark brown oil. The crude product mixture was purified via flash chromatography (silica gel, gradient elution: ethyl acetate to 9/1 ethyl acetate/methanol) to yield 8.099 g (70%) of non-polydispersed 16 as a yellow oil.

出典