反応 #671111

反応方程式

chlorosulfonic acid

1-methylindoline

→

desired product

1-methyl-5-indolinesulfonyl chloride

反応条件

後処理

1. 1
   温度heated at 75° C. for 40 minutes
2. 2
   温度cooled
3. 3
   workup.ADDITIONpoured onto ice
4. 4
   その他to provide a solid
5. 5
   ろ過The solid was collected by suction filtration
6. 6
   洗浄washed with water
7. 7
   その他dried

実験手順

A solution of chlorosulfonic acid at 0° C. (5 mL, 75 mmol) was treated portionwise with 1-methylindoline (CAS No. [824-21-5], 1.96 g, 14.7 mmol), warmed to room temperature, heated at 75° C. for 40 minutes, cooled, and poured onto ice to provide a solid. The solid was collected by suction filtration, washed with water, and dried to provide 927 mg of the desired product.

出典