反応 #67042

反応方程式

methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate

2,4-dichlorobenzyl amine

1,4-dioxane

→

methyl 2-(2,4-dichlorobenzylamino)-4-(trifluoromethyl)pyrimidine-5-carboxylate

溶媒

ethyl acetate

反応条件

後処理

1. 1
   その他To the reaction liquid
2. 2
   洗浄washed with saturated brine (10 mL)
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   その他the solvent was evaporated under reduced pressure
5. 5
   その他The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate)

実験手順

A mixture of methyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (0.30 g), 2,4-dichlorobenzyl amine (818 μL), and 1,4-dioxane (3 mL) was stirred at room temperature for 21 hours. To the reaction liquid was added ethyl acetate (30 mL), washed with saturated brine (10 mL), and dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate) to obtain methyl 2-(2,4-dichlorobenzylamino)-4-(trifluoromethyl)pyrimidine-5-carboxylate (446 mg) as a colorless solid.

出典