反応 #66988

反応方程式

3-(2-methylphenyl)-2-[(Z)-isopropylimino]-thiazolidin-4-one

2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde

sodium acetate

→

5-(2,3-dihydro-benzo[1,4]dioxin-6-ylmeth-(Z)-ylidene)-2-[(Z)-isopropylimino]-3-o-tolyl-thiazolidin-4-one

溶媒

acetic acid

反応条件

後処理

1. 1
   その他HPLC purification
2. 2
   workup.ADDITIONThe product containing fractions
3. 3
   その他are evaporated
4. 4
   その他dried

実験手順

A solution of 3-(2-methylphenyl)-2-[(Z)-isopropylimino]-thiazolidin-4-one (50 mg, 0.200 mmol), 2,3-dihydro-benzo[1,4]dioxine-6-carbaldehyde (49 mg, 0.300 mmol) and sodium acetate (33 mg, 0.400 mmol) in acetic acid (1 mL) is stirred at 110° C. for 5 h. The reaction mixture is cooled to rt and subjected to prep. HPLC purification. The product containing fractions are evaporated and dried to give 5-(2,3-dihydro-benzo[1,4]dioxin-6-ylmeth-(Z)-ylidene)-2-[(Z)-isopropylimino]-3-o-tolyl-thiazolidin-4-one.

出典