反応 #66974

反応方程式

N-Ethylbenzylamine

diisopropylethylamine

Phosgene

→

title compound

Benzyl-ethyl-carbamyl chloride

溶媒

CH2Cl2

反応条件

後処理

1. 1
   濃縮The mixture was concentrated
2. 2
   workup.ADDITIONthe residue was diluted with diethyl ether (150 mL)
3. 3
   洗浄washed twice with H2O
4. 4
   その他The organic layer was dried
5. 5
   濃縮concentrated

実験手順

N-Ethylbenzylamine (0.56 mL, 3.8 mmol) and diisopropylethylamine (1 mL, 5.7 mmol) were combined in CH2Cl2 (12 mL) and cooled to 0° C. Phosgene (1.9M in toluene; 2.4 mL, 4.6 mmol) was added over 5 minutes, and the reaction was stirred at room temperature overnight. The mixture was concentrated, and the residue was diluted with diethyl ether (150 mL) and washed twice with H2O. The organic layer was dried and concentrated to give the title compound.

出典