反応 #66938

反応方程式

165

2-(3-Benzyloxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one

→

166

収率 77.0%

2-(3-Hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one

収率 77.0%

溶媒

methanol

反応条件

後処理

1. 1
   その他The precipitate were collected
2. 2
   workup.DISSOLUTIONdissolved in 10% NaOH solution
3. 3
   ろ過filtered
4. 4
   その他the precipitate was then collected
5. 5
   洗浄washed with acetone and water

実験手順

A suspension of 0.5 g (1.245 mmol) of 165 and 0.25 g of palladium (10 wt % on activated carbon) in 60 mL of methanol was stirred at room temperature under hydrogen gas atmosphere for 24 h. The precipitate were collected and dissolved in 10% NaOH solution and then filtered. The filtrate was acidified with dil aq HCl and the precipitate was then collected and washed with acetone and water to give 166.

出典