反応 #66936

反応方程式

163

3-(Benzyloxy)-5-methoxybenzoyl chloride

triethylamine

2-amino-4,5-methylenedioxy acetophenone

→

164

N-(6-acetylbenzo[d][1,3]-dioxol-5-yl)-3-(benzyloxy)-5-methoxybenzamide

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他evaporated
2. 2
   その他The residue was purified by column chromatography (SiO2, CH2Cl2/EtOAc=3/1)

実験手順

Into solutions of 163 (2.77 g, 0.01 mmol) in 200 mL of dry tetrahydrofuran were added triethylamine (10 mL) and 2-amino-4,5-methylenedioxy acetophenone (148) (1.79 g, 0.01 mmol). The mixtures were stirred at room temperature for 24 h and then evaporated. The residue was purified by column chromatography (SiO2, CH2Cl2/EtOAc=3/1) to give 164.

出典