反応 #66930

反応方程式

KBr

potassium t-butoxide

155

N-(6-Acetyl-1,3-benzodioxol-5-yl)-1-benzofuran-3-carboxamide

ammonium chloride

→

2-(3-Benzo[b]furyl)-6,7-methylenedioxyquinolin-4-one

収率 17.0%

溶媒

t-butyl alcohol

反応条件

後処理

1. 1
   温度The mixture was refluxed under argon for 12 h
2. 2
   温度cooled
3. 3
   その他The solid precipitate was collected
4. 4
   洗浄washed with EtOH
5. 5
   その他The crude product was purified by flash chromatography (silica gel, CH2Cl2: EtOH 16:1-10:1)
6. 6
   その他Obtained as a pale-yellow solid from 155

実験手順

Into a suspension of 155 (2.95 mmol) in t-butyl alcohol (100 mL) was added potassium t-butoxide (1.66 g, 14.7 mmol). The mixture was refluxed under argon for 12 h, cooled, and poured into a 10% ammonium chloride solution (100 mL). The solid precipitate was collected and washed with EtOH. The crude product was purified by flash chromatography (silica gel, CH2Cl2: EtOH 16:1-10:1). Obtained as a pale-yellow solid from 155; yield 17%; mp>315° C.; ESI-MS (Positive mode): m/z 306 [M+H]+; 1H-NMR (400 MHz, DMSO-d6): δ 6.12 (2H, s), 6.49 (1H, s), 7.13 (1H, s), 7.36-7.45 (3H, m), 7.69 (1H, d, J=8.0 Hz), 8.14 (1H, s), 8.52 (1H, s); IR (KBr): 1626 (C═O) cm−1; Anal. Calcd for C18H11NO4: C, 70.82; H, 3.63; N, 4.59. Found: C, 70.52; H, 3.95; N, 4.21.

出典