反応 #669192

反応方程式

compound

2-cyano-3-methylthio-3-(4-tolyl)acrylamide

2-cyano-3-methylthio-3-(4-tolyl)acrylamide

2-hydrazinopyridine

→

title compound

5-Amino-1-(2-pyridyl)-3-(4-tolyl)pyrazole-4-carboxamide

反応条件

実験手順

The title compound was prepared from 2-cyano-3-methylthio-3-(4-tolyl)acrylamide (4.64 mg, 2.0 mmol) and 2-hydrazinopyridine (218 mg, 2.0 mmol) following the procedure used for the compound of Example 12. The title compound was obtained as a white crystalline solid (350 mg) m.p. 244-247°. δH (d6DMSO) 8.46 (1H, dm, J 5.0 Hz), 7.97 (1H, ddd, J 8.4, 7.4, 1.9 Hz), 7.85 (1H, d, J 8.4 Hz), 7.68 (2H, br s), 7.47 (2H, d, J 8.1 Hz), 7.31 (2H, d, J 7.6 Hz), 7.29 (1H, signal obscured by overlapping d), 3.30 (2H, s) and 2.37 (3H, s). MS (ES+) 294 (MH+, 100%).

出典