反応 #66895

反応方程式

N-(3,4-dichlorophenyl)-5,6,7,8-tetrahydropyrido[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine

N-(3,4-Dichlorophenyl)-5,6,7,8-tetrahydropyrido[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine

(2E)-4-[methyl(1-methylethyl)amino]but-2-enoic acid hydrochloride

→

title compound

N-(3,4-Dichlorophenyl)-6-{(2E)-4-[methyl(1-methylethyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine

反応条件

後処理

1. 1
   その他to yield 56 mg (40%)

実験手順

The title compound was synthesized in analogy to Example 89 from N-(3,4-dichlorophenyl)-5,6,7,8-tetrahydropyrido[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 76A (100 mg, 0.29 mmol) and (2E)-4-[methyl(1-methylethyl)amino]but-2-enoic acid hydrochloride from Example 2A (77 mg, 0.40 mmol) to yield 56 mg (40%).

出典