反応 #66883

反応方程式

(2E)-4-bromobut-2-enoic acid

3-chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

3-Chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

bis(2-methoxyethyl)amine

→

title compound

3-[(7-{(2E)-4-[Bis(2-methoxyethyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-yl)amino]-5-chlorophenol

反応条件

後処理

1. 1
   その他to yield 42 mg (29%)

実験手順

In analogy to Example 130, the title compound was prepared from (2E)-4-bromobut-2-enoic acid (84 mg, 0.41 mmol), 3-chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 65A (100 mg, 0.27 mmol) and bis(2-methoxyethyl)amine (58 mg, 0.43 mmol) to yield 42 mg (29%).

出典