反応 #66871

反応方程式

N-(3-ethynylphenyl)-5,6,7,8-tetrahydropyrido[4′,3′:4,5]furo[2,3-d]pyrimidin-4-amine

N-(3-Ethynylphenyl)-5,6,7,8-tetrahydropyrido[4′,3′:4,5]furo[2,3-d]pyrimidin-4-amine

(2E)-4-(dimethylamino)but-2-enoic acid hydrochloride

(2E)-4-(Dimethylamino)but-2-enoic acid hydrochloride

→

title compound

7-[(2E)-4-(Dimethylamino)but-2-enoyl]-N-(3-ethynylphenyl)-5,6,7,8-tetrahydropyrido[4′,3′:4,5]furo[2,3-d]pyrimidin-4-amine

反応条件

後処理

1. 1
   その他to yield 66 mg (46%)

実験手順

In analogy to Example 89, the title compound was prepared from N-(3-ethynylphenyl)-5,6,7,8-tetrahydropyrido[4′,3′:4,5]furo[2,3-d]pyrimidin-4-amine from Example 43A (100 mg, 0.344 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (80 mg, 0.48 mmol) to yield 66 mg (46%).

出典