反応 #668583

反応方程式

1-([1,1'-biphenyl]-2-ylmethyl)-4-methoxy-2-methyl-1H-indole

→

1-([1,1'-biphenyl]-2-ylmethyl)-4-hydroxy-2-methyl-1H-indole

収率 55.0%

溶媒

BBr3 CH2Cl2

反応条件

後処理

1. 1
   その他The crude product was chromatographed on silica gel
2. 2
   洗浄eluted with 20% EtOAc/hexane

実験手順

By the method used in Example 1, Part D, 1.6 g (4.9 mmol) of 1-([1,1'-biphenyl]-2-ylmethyl)-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 20 mL of 1M BBr3 /CH2Cl2. The crude product was chromatographed on silica gel and eluted with 20% EtOAc/hexane to give 841 mg (55% yield) of 1-([1,1'-biphenyl]-2-ylmethyl)-4-hydroxy-2-methyl-1H-indole.

出典