反応 #6682

反応方程式

KOH

ethyl 4-benzyloxybenzoate

→

4-Benzyloxybenzoic acid

溶媒

MeOH

反応条件

後処理

1. 1
   温度After the resulting mixture was refluxed for 4 hrs
2. 2
   その他the excess methanol was removed
3. 3
   workup.ADDITIONThe residue was mixed with 30 ml water
4. 4
   抽出extracted with ether twice
5. 5
   抽出extracted with ethyl acetate
6. 6
   洗浄The ethyl acetate solution was washed with brine
7. 7
   その他dried
8. 8
   その他After evaporation of solvent
9. 9
   その他pure product was obtained in quantitative yield

実験手順

To the solution of 0.5 g KOH in 40 ml MeOH, was added 6.5 mmol of ethyl 4-benzyloxybenzoate. After the resulting mixture was refluxed for 4 hrs, the excess methanol was removed. The residue was mixed with 30 ml water and extracted with ether twice. The water solution was acidified with conc. HCl and extracted with ethyl acetate. The ethyl acetate solution was washed with brine and dried. After evaporation of solvent, pure product was obtained in quantitative yield.

出典