反応 #6681

反応方程式

Cs2CO3

benzyl bromide

BzBn

ethyl 4-hydroxybenzoate

→

Ethyl 4-benzyloxybenzoate

収率 100.0%

溶媒

DMF

water

反応条件

後処理

1. 1
   その他the product was collected by extraction
2. 2
   洗浄The organic solution was washed with brine
3. 3
   乾燥dried over MgSO4
4. 4
   その他After evaporation of solvent
5. 5
   その他pure product was obtained in yield of 100%

実験手順

35 mmol of benzyl bromide (BzBn, 35 mmol of ethyl 4-hydroxybenzoate (10), 14 g of Cs2CO3 and 40 ml of DMF were combined and stirred at RT ove night. Then the reaction mixture was poured into water and the product was collected by extraction. The organic solution was washed with brine and dried over MgSO4. After evaporation of solvent, pure product was obtained in yield of 100%.

出典