反応 #66780

反応方程式

CDI

thieno(3,4-c)furan-1,3-dione

3-amino-3-methylpiperidin-2,6-dione

→

solid

収率 79.1%

5-(3-methyl-2,6-dioxopiperidin-3-yl)-5H-thieno(3,4-c)pyrrole-4,6-dione

収率 79.1%

溶媒

THF

反応条件

後処理

1. 1
   その他to react at room temperature for 4 h
2. 2
   温度to reflux for 6 h during which time a solid
3. 3
   その他precipitated
4. 4
   温度The reaction solution was cooled
5. 5
   ろ過filtered

実験手順

1.54 g of thieno(3,4-c)furan-1,3-dione was dissolved in 20 mL of anhydrous THF, and 1.42 g of 3-amino-3-methylpiperidin-2,6-dione was added. The reaction mixture was allowed to react at room temperature for 4 h, and 2 g of CDI and a catalytic quantity of DMAP were added. The reaction mixture was allowed to reflux for 6 h during which time a solid precipitated. The reaction solution was cooled and filtered to obtain a white solid (2.2 g). MS (m/z): 278 (M)+.

出典