反応 #6673

反応方程式

phenothiazine

iodoethane

potassium hydroxide

→

10-Ethylphenothiazine

溶媒

toluene

反応条件

後処理

1. 1
   温度was refluxed for 24 hours
2. 2
   温度After cooling
3. 3
   ろ過the reaction mixture was filtered
4. 4
   その他the solvent was evaporated
5. 5
   その他The product was crystallized from methanol

実験手順

A mixture of 10 g (0.05 mol) of phenothiazine, 11.7 g (0.075 mol) of iodoethane, 4.2 g (0.075 mol) of potassium hydroxide and 0.25 g of tetra-n-butylammonium hydrogen sulfate in 200 ml of dry toluene was refluxed for 24 hours. After cooling, the reaction mixture was filtered, and the solvent was evaporated. The product was crystallized from methanol. The yield of 10-ethylphenothiazine (C14H13NS, FW=227.33) was 90%.

出典