反応 #66673

反応方程式

H2O

1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene

KF

trifluoromethyl iodide

→

1-Isopropyl-5-methoxy-2-(toluene-4-sulfonyl)-4-trifluoromethyl-benzene

収率 107.9%

溶媒

DMF

反応条件

後処理

1. 1
   温度The reaction mixture was heated for 4 hrs
2. 2
   ろ過The insoluble solid, which was collected by filtration
3. 3
   その他was triturated with methylene chloride
4. 4
   ろ過filtered
5. 5
   濃縮concentrated

実験手順

To a hot mixture of 1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene (0.5 g, 1.12 mmol), CuI, KF in anhydrous DMF (10 ml) at 120° C. oil bath temperature, was added trifluoromethyl iodide (0.64 g, 4.48 mmol) in portions over 30 min. The reaction mixture was heated for 4 hrs and poured into H2O (100 ml). The insoluble solid, which was collected by filtration was triturated with methylene chloride, filtered and concentrated to give 1-Isopropyl-5-methoxy-2-(toluene-4-sulfonyl)-4-trifluoromethyl-benzene (0.45 g, 100%) as a solid.

出典