反応 #66571

反応方程式

Water

product

1-[[2-Hydroxy-5-(1-methylethyl)phenyl]methyl]-4-(phenylsulfonyl)-piperazine

ethyl bromoacetate

potassium carbonate

→

sub-title compound

Ethyl[4-(1-methylethyl)-2-[[4-(phenylsulfonyl)-1-piperazinyl]methyl]phenoxy]-acetate

溶媒

acetone

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 2 days
3. 3
   抽出the mixture was extracted with diethyl ether
4. 4
   乾燥The organic extracts were dried (MgSO4)
5. 5
   その他evaporated in vacuo
6. 6
   その他purified by chromatography (silica, petrol—ether as eluent)

実験手順

A mixture of the product from step (d) (244 mg), ethyl bromoacetate (0.1 ml) and potassium carbonate (185 mg) in acetone was heated under reflux for 2 days. Water was added and the mixture was extracted with diethyl ether. The organic extracts were dried (MgSO4), evaporated in vacuo and purified by chromatography (silica, petrol—ether as eluent) to give the sub-title compound (113 mg).

出典