反応 #66533

反応方程式

4-(Trifluoromethyl)-phenol

dihydropyran

→

sub-title compound

収率 133.3%

Tetrahydro-2-[4-(trifluoromethyl)phenoxy]-2H-pyran

収率 133.3%

溶媒

dichloromethane

dichloromethane

HCl

反応条件

後処理

1. 1
   その他to reach room temperature
2. 2
   その他quenched with saturated sodium bicarbonate (×1)
3. 3
   その他The organic layer was separated
4. 4
   乾燥dried (MgSO4)
5. 5
   濃縮concentrated in vacuo

実験手順

A solution of 4-(Trifluoromethyl)-phenol (40 g) in dichloromethane (100 ml) was added at 0° C. dropwise to a solution of dihydropyran (53 g) in dichloromethane (100 ml) and aqueous HCl (200 μl) The reaction was allowed to reach room temperature, then quenched with saturated sodium bicarbonate (×1). The organic layer was separated and dried (MgSO4), concentrated in vacuo to give the sub-title compound (81 g)

出典