反応 #66516

反応方程式

thiophene-2-carbonyl chloride

3-methoxyaniline

DIEA

→

N-(3-methoxyphenyl)thiophene-2-carboxamide

収率 70.1%

溶媒

DCM

DCM

反応条件

後処理

1. 1
   洗浄The organic phase was washed with HCl 1 M solution
2. 2
   乾燥with a saturated solution of NaHCO3, was dried over MgSO4
3. 3
   ろ過was filtered
4. 4
   濃縮was concentrated under reduced pressure

実験手順

According to Scheme 1 Method A: A solution of thiophene-2-carbonyl chloride (2.92 mmol, 0.31 mL) in DCM (1 mL) was added to solution of 3-methoxyaniline (2.44 mmol, 0.27 mL) and DIEA (4.87 mmol, 0.87 mL) in DCM (4 mL) at 0° C. The reaction mixture was stirred at room temperature for 1 hour. The organic phase was washed with HCl 1 M solution, then with a saturated solution of NaHCO3, was dried over MgSO4, was filtered and was concentrated under reduced pressure to yield N-(3-methoxyphenyl)thiophene-2-carboxamide (1.71 mmol, 0.40 g, 70%) as a white solid.

出典