反応 #66513

反応方程式

4-iodo-1H-pyrazole

1-(chloromethyl)-4-methoxybenzene

K2CO3

→

4-iodo-1-(4-methoxybenzyl)-1H-pyrazole

収率 88.2%

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度The reaction mixture was cooled to room temperature
2. 2
   ろ過was filtered
3. 3
   濃縮The filtrate was concentrated under reduced pressure
4. 4
   その他The crude product was purified by flash chromatography over silica gel

実験手順

According to Scheme 6 Step 1: A suspension of 4-iodo-1H-pyrazole (26.3 mmol, 5.11 g), 1-(chloromethyl)-4-methoxybenzene (29.0 mmol, 3.95 mL) and K2CO3 (39.5 mmol, 5.46 g) in acetonitrile (150 mL) was heated at 60° C. overnight. The reaction mixture was cooled to room temperature and was filtered. The filtrate was concentrated under reduced pressure. The crude product was purified by flash chromatography over silica gel using DCM as eluent to afford 4-iodo-1-(4-methoxybenzyl)-1H-pyrazole (23.2 mmol, 7.3 g, 88%) as a yellow solid.

出典