反応 #66494

反応方程式

3-amino-1-propanol

N-ethyldiisopropylamine

2,4-dichloro-5-iodo-pyrimidine

→

3-(2-chloro-5-iodopyrimidine-4-ylamino)propan-1-ol

収率 95.0%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他provided the target compound after column chromatography in 95% yield

実験手順

In analogy to GP 2 reaction of 3-amino-1-propanol (0.38 ml, 5 mmol) in the presence of N-ethyldiisopropylamine (1.74 ml, 10 mmol) in 150 ml acetonitrile with 2,4-dichloro-5-iodo-pyrimidine (1.51, 5.5 mmol) provided the target compound after column chromatography in 95% yield.

出典