反応 #66491

反応方程式

(R)-2-aminopropanol

2,4-dichloro-5-iodopyrimidine

triethylamine

→

title compound

収率 88.0%

(R)-2-(2-chloro-5-iodopyrimdin-4-ylamino)propan-1-ol

収率 88.0%

溶媒

ethyl acetate

acetonitrile

反応条件

後処理

1. 1
   抽出followed by extraction with brine, 10% aqueous citric acid, and aqueous sodium bicarbonate
2. 2
   乾燥After drying over sodium sulfate
3. 3
   その他the solvent was evaporated
4. 4
   その他the residue was purified by column chromatography

実験手順

To a solution of 2,4-dichloro-5-iodopyrimidine (3.0 g; 10.9 mol) in acetonitrile (35 mL) was added triethylamine (1.32 g, 1.82 mL, 13.1 mmol), followed by (R)-2-aminopropanol (0.88 g, 11.8 mmol). The mixture was stirred at room temperature for 24 h and was then diluted with ethyl acetate, followed by extraction with brine, 10% aqueous citric acid, and aqueous sodium bicarbonate. After drying over sodium sulfate, the solvent was evaporated and the residue was purified by column chromatography to give the title compound (3.0 g, 88% yield).

出典