反応 #66458

反応方程式

8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one

triethylamine hydrochloride

POCl3

→

solid

収率 89.0%

4-Chloro-8-methoxy-2-(2-trifluoromethyl-phenyl)-quinazoline

収率 89.0%

反応条件

後処理

1. 1
   その他Purification by flash chromatography

実験手順

Prepared from 8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one (1.0 g, 3.12 mmol), triethylamine hydrochloride (472 mg, 3.43 mmol), and POCl3. Purification by flash chromatography afforded a white solid (89% yield). HPLC-Method A, Rt 4.10 min, (98%), MS (m/z) 258.08 (M+H).

出典