反応 #66420

反応方程式

(4-aminophenyl)-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide

phthalic anhydride

→

desired compound

収率 55.0%

[4-(1,3-dioxobenzo[c]azolidin-2-yl)phenyl]-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide

収率 55.0%

溶媒

DMF

反応条件

後処理

1. 1
   温度the mixture was cooled
2. 2
   その他purified by RP-HPLC

実験手順

A 22 mg portion (0.070) of (4-aminophenyl)-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide was combined with 15 mg (0.10 mmol) of phthalic anhydride in 140 μL of DMF. After 18 h of heating at 110° C., the mixture was cooled and purified by RP-HPLC, to give 20 mg (55%) of the desired compound. ES-MS (M+H)+=447 (Cl).

出典