反応 #66396

反応方程式

tert-butyl(trans)-2-(1,1′-biphenyl-4-yl)cyclopropyl(2-(4-methylpiperazin-1-yl)-2-oxoethyl)carbamate

Et2O.HCl

→

2-((trans)-2-(1,1′-biphenyl-4-yl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone

収率 15.0%

溶媒

Et2O

反応条件

後処理

1. 1
   その他After completion reaction mixture
2. 2
   ろ過was filtered under inert atmosphere
3. 3
   洗浄washed with hexane and EtOAC
4. 4
   その他dried under reduced pressure

実験手順

To a solution of tert-butyl(trans)-2-(1,1′-biphenyl-4-yl)cyclopropyl(2-(4-methylpiperazin-1-yl)-2-oxoethyl)carbamate derivative (1 equiv) in Et2O at 0° C. was added Et2O.HCl slowly drop wise, stirred for 1 h at 0° C. to RT. The progress of the reaction was monitored by TLC. After completion reaction mixture was filtered under inert atmosphere and washed with hexane and EtOAC, and dried under reduced pressure to get 2-((trans)-2-(1,1′-biphenyl-4-yl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone derivative (Overall yield 15%).

出典