反応 #66324

反応方程式

2,4-Dichloropyrimidine-5-carbonyl chloride

2,2,2-trifluoroethylamine

triethylamine

→

solid

収率 60.0%

2,4-dichloro-pyrimidine-5-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

収率 60.0%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   その他The reaction mixture was purified by flash chromatography

実験手順

2,4-Dichloropyrimidine-5-carbonyl chloride (1 g, 5 mmol) was dissolved in CH2Cl2 (20 mL), 2,2,2-trifluoroethylamine (515 mg, 5 mmol) and triethylamine (1.31 mL, 9 mmol) were added. The reaction mixture was stirred at 25° C. for 2 h. The reaction mixture was purified by flash chromatography to yield a white solid (780 mg, 60%). MS: m/z=271.9 [M−H]−.

出典