反応 #66322

反応方程式

(S)-3-(2-Trifluoromethyl-benzenesulfonyl)-pyrrolidine

4-Chloro-2-(methylsulfanyl)-6-(trifluoromethyl)pyrimidine

KF

→

2-Methylsulfanyl-4-trifluoromethyl-6-[(S)-3-(2-trifluoromethyl-benzenesulfonyl)-pyrrolidin-1-yl]-pyrimidine

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他The reaction mixture was irradiated in the microwave oven at 150° C. for 1.5 h
2. 2
   その他The reaction mixture was evaporated to dryness
3. 3
   その他purified by flash chromatography (50 g silica gel, ethyl acetate/n-heptane:0:1→1:0)
4. 4
   その他to yield a light yellow oil (790 mg; 94%)

実験手順

(S)-3-(2-Trifluoromethyl-benzenesulfonyl)-pyrrolidine (500 mg) was dissolved in acetonitrile (3.5 mL) in a microwave tube. 4-Chloro-2-(methylsulfanyl)-6-(trifluoromethyl)pyrimidine (450 mg), TEA (0.75 mL) and KF (10 mg) were added. The reaction mixture was irradiated in the microwave oven at 150° C. for 1.5 h. The reaction mixture was evaporated to dryness and purified by flash chromatography (50 g silica gel, ethyl acetate/n-heptane:0:1→1:0) to yield a light yellow oil (790 mg; 94%) MS: m/z=472.2 [M+H]+.

出典