反応 #66172

反応方程式

compound

Ethyl (5-bromopyridin-3-yl)acetate

dimethylformamide diethyl acetal

→

Ethyl 3-(dimethylamino)-2-(5-bromopyridin-3-yl)acrylate

反応条件

後処理

1. 1
   温度After cooling
2. 2
   濃縮the mixture is concentrated under reduced pressure
3. 3
   ろ過the solid is filtered off
4. 4
   洗浄finally washed with diisopropyl ether
5. 5
   乾燥The crude product is dried under reduced pressure for 16 h.

実験手順

5.1 g (20.9 mmol) of the compound from Example 10A are stirred in 7.2 ml (6.2 g, 41.8 mmol) of dimethylformamide diethyl acetal at a bath temperature of 100° C. for 16 h. After cooling, the mixture is concentrated under reduced pressure, the residue is stirred in diisopropyl ether, and the solid is filtered off and finally washed with diisopropyl ether. The crude product is dried under reduced pressure for 16 h.

出典