反応 #66161

反応方程式

compound

Ethyl (6-chloropyridin-3-yl)acetate

dimethylformamide diethyl acetal

→

Ethyl 2-(6-chloropyridin-3-yl)-3-(dimethylamino)acrylate

反応条件

後処理

1. 1
   濃縮The mixture is then concentrated on a rotary evaporator
2. 2
   その他the residue is chromatographed on silica gel 60 (mobile phase: dichloromethane→dichloromethane/methanol 20:1)

実験手順

3.99 g (20.0 mmol) of the compound from Example 1A are dissolved in 13.7 ml of dimethylformamide diethyl acetal, and the mixture is stirred with microwave irradiation at 90° C. for 30 min. The mixture is then concentrated on a rotary evaporator, and the residue is chromatographed on silica gel 60 (mobile phase: dichloromethane→dichloromethane/methanol 20:1).

出典