反応 #661502

反応方程式

Isopropyl bromide

2-mercapto-3-(2-methoxy-phenyl)-7-methyl-3H-quinazolin-4-one

potassium carbonate

→

2-isopropylsulfanyl-3-(2-methoxy-phenyl)-7-methyl-3H-quinazolin-4-one

収率 59.4%

溶媒

acetone

反応条件

後処理

1. 1
   温度the mixture was heated
2. 2
   温度at reflux for 16 hr
3. 3
   ろ過the any solid were filtered
4. 4
   洗浄washed with acetone
5. 5
   濃縮The filtrate was concentrated to dryness in vacuo
6. 6
   その他the crude compound was purified by column chromatography over silica gel (100-200 mesh)

実験手順

Isopropyl bromide (0.11 mL, 1.25 mmol) was added to a suspension of 2-mercapto-3-(2-methoxy-phenyl)-7-methyl-3H-quinazolin-4-one (250 mg, 0.84 mmol) and potassium carbonate (235 mg, 1.68 mmol) in acetone (10 mL) and the mixture was heated at reflux for 16 hr. The reaction mixture was cooled to room temperature and the any solid were filtered and washed with acetone. The filtrate was concentrated to dryness in vacuo and the crude compound was purified by column chromatography over silica gel (100-200 mesh) using 5% ethyl acetate in pet ether as eluent to afford 2-isopropylsulfanyl-3-(2-methoxy-phenyl)-7-methyl-3H-quinazolin-4-one (170 mg, 59%) as semi solid.

出典