反応 #661289

反応方程式

1d

3-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid methyl ester

methanol sodium hydroxide

→

3-({2-[(4-Cyano-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid

反応条件

後処理

1. 1
   その他evaporated to dryness
2. 2
   workup.STIRRINGThe remaining solid was stirred with 100 mL water
3. 3
   その他The precipitated product was isolated by filtration
4. 4
   洗浄washed with water
5. 5
   その他dried at 60° C.

実験手順

To a solution of the product of 1d (13.0 mmol) in 100 mL methanol sodium hydroxide (20.0 mmol) was added. The mixture was stirred for 2.5 hours at 40° C. and then evaporated to dryness. The remaining solid was stirred with 100 mL water and the pH was adjusted to about 6 with concentrated acetic acid. The precipitated product was isolated by filtration, washed with water and dried at 60° C.

出典