反応 #6611

反応方程式

water

2-bromomethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene

ethyl 4-hydroxybenzoate

potassium carbonate

→

title compound

収率 50.8%

4-Carbethoxyphenyl 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylmethyl ether

収率 50.8%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   抽出extracted several times with ether
2. 2
   洗浄the organic phase was washed with water
3. 3
   乾燥dried over Na2SO4
4. 4
   濃縮concentrated
5. 5
   その他Recrystallization from methanol

実験手順

10 g (36 mmol) of 2-bromomethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene, 6 g (36 mmol) of ethyl 4-hydroxybenzoate and 7.2 g (52 mmol) of anhydrous potassium carbonate in 60 ml of dimethylformamide were refluxed for 5.25 h. The mixture was then poured into water and extracted several times with ether, and the organic phase was washed with water, dried over Na2SO4 and concentrated. Recrystallization from methanol resulted in 6.7 g of the title compound of melting point 109°-11° C.

出典