反応 #66056

反応方程式

HCl

2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole

HCl

2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole

→

2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride salt

溶媒

isopropyl acetate

IPAC

反応条件

後処理

1. 1
   その他HCl (gas) may be bubbled into the slurry for about 1 hour
2. 2
   ろ過after which the mixture may be filtered
3. 3
   洗浄washed with IPAC
4. 4
   その他dried under vacuum at room temperature

実験手順

An alternate method for conversion of the sulfonate or halide salts of 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole to an HCl salt involves the use of a concentrated solution of HCl and isopropyl acetate (IPAC). A sulfonate or halide salt of 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole may be taken up in IPAC and cooled to 15° C. HCl (gas) may be bubbled into the slurry for about 1 hour, after which the mixture may be filtered, washed with IPAC and dried under vacuum at room temperature to afford a 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride salt. A detailed example of this synthesis may be found in Example 9.

出典