反応 #66035

反応方程式

water

carbazole

4-fluoroacetophenone

K2CO3

→

product

1-(4-Carbazol-9-yl-phenyl)ethanone

溶媒

DMSO

反応条件

後処理

1. 1
   その他to afford a precipitate
2. 2
   その他which is isolated by filtration
3. 3
   洗浄washed with water
4. 4
   その他The crude product thus obtained
5. 5
   その他is further purified by recrystallization from TBME (tert-butyl methyl ether)

実験手順

To carbazole (5.02 g) in DMSO (50 mL) is added 4-fluoroacetophenone (3.45 g) and K2CO3 (10.4 g), and the mixture is stirred at 135° C. overnight. The mixture is poured into water to afford a precipitate, which is isolated by filtration and washed with water. The crude product thus obtained is further purified by recrystallization from TBME (tert-butyl methyl ether), giving the product as a light brown solid. The structure is confirmed by the 1H-NMR spectrum (CDCl3). δ [ppm]: 2.71 (s, 3H), 7.32 (ddd, 2H), 7.41-7.50 (m, 4H), 7.72 (d, 2H), 8.15 (d, 2H), 8.21 (d, 2H).

出典