反応 #65967

反応方程式

1-naphthol

piperidine

formaldehyde

→

2-(piperidinomethyl)-1-naphthol

収率 45.0%

反応条件

後処理

1. 1
   その他the following reaction scheme

実験手順

Brown (Bull. Natl. Inst. Sci. India, No. 31, 167-178, 1965) discloses the following reaction scheme: Mannich reaction of 1-naphthol with piperidine and formaldehyde afforded 2-(piperidinomethyl)-1-naphthol in a yield of 45%. Reduction of 2-(piperidinomethyl)-1-naphthol in the presence of H2 /Pd/SrCO3 afforded 2-methyl-1-naphthol in a yield of 85%.

出典