反応 #65961

反応方程式

sodium borohydride

1-Hydroxy-2-naphthoic acid

1-hydroxy-2-naphthoic acid

methyl chloroformate

1-naphthol

1-hydroxy-2-naphthoic acid

→

2-methyl-naphthol

収率 80.0%

溶媒

THF

triethylamine

反応条件

後処理

1. 1
   その他was obtained in a yield of 60%

実験手順

1-naphthol (5) was heated with twice its weight of KHCO3 at 200° C. for 5 hours (stainless steel bomb) whereby 1-hydroxy-2-naphthoic acid (9) was obtained in a yield of 60%. 1-Hydroxy-2-naphthoic acid (9) was treated with methyl chloroformate and triethylamine in THF, followed by sodium borohydride reduction, whereby 2-methyl-naphthol (I) was produced in a yield of 80%.

出典