反応 #6595

反応方程式

sodium

allyl bromide

ethyl 4-cyclohexyloxy-acetoacetate

→

Ethyl 2-(cyclohexyloxyacetyl)-4-pentenoate

溶媒

ethanol

反応条件

後処理

1. 1
   その他fitted with a stirrer
2. 2
   その他drying tube
3. 3
   温度reflux condenser
4. 4
   workup.ADDITIONis added at 50° C. in the course of 30 minutes
5. 5
   その他are then metered in at 50°-60° C. in the course of 30 minutes
6. 6
   温度while cooling
7. 7
   workup.DISTILLATIONthe ethanol is then distilled off
8. 8
   その他After the phases have been separated
9. 9
   抽出the aqueous phase is extracted twice with 750 ml of toluene each time
10. 10
    濃縮concentrated
11. 11
    workup.DISTILLATIONthe residue is distilled

実験手順

320 g of ethyl 4-cyclohexyloxy-acetoacetate (1.4 mol) are initially introduced into a threenecked flask fitted with a stirrer, dropping funnel, drying tube and reflux condenser, and an Na ethanolate solution prepared from 32 g of sodium (1.4 mol) and 475 g of ethanol is added at 50° C. in the course of 30 minutes. 170 g of allyl bromide (1.4 mol) are then metered in at 50°-60° C. in the course of 30 minutes, while cooling. The mixture is subsequently stirred at 50° C. for 2 hours, the ethanol is then distilled off and the reaction mixture which remains is brought to pH=3 with hydrochloric acid. After the phases have been separated, the aqueous phase is extracted twice with 750 ml of toluene each time, the organic phases are combined and concentrated and the residue is distilled. Ethyl 2-(cyclohexyloxyacetyl)-4-pentenoate is obtained. (Temperature (bottom)=152°-179° C., temperature (top)=102°-127° C.; 1 mbar).

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