反応 #659355

反応方程式

1-(2-Chloropyridin-3-yl)propan-1-one

[4-(benzyloxy)phenyl]hydrazine hydrochloride

→

title compound

収率 25.7%

1-[4-(Benzyloxy)phenyl]-3-ethyl-1H-pyrazolo[3,4-b]pyridine

収率 25.7%

溶媒

ethanol

反応条件

後処理

1. 1
   濃縮concentrated
2. 2
   その他The residue was purified by basic silica gel column chromatography (hexane/ethyl acetate)

実験手順

1-(2-Chloropyridin-3-yl)propan-1-one (600 mg) and [4-(benzyloxy)phenyl]hydrazine hydrochloride (976 mg) were dissolved in ethanol (10 ml), and the mixture was stirred under microwave irradiation at 170° C. for 3 hr, and concentrated. The residue was purified by basic silica gel column chromatography (hexane/ethyl acetate) to give the title compound (300 mg). MS (API+): [M+H]+ 330.1.

出典