反応 #65903

反応方程式

HCl

HCl

sodium cyanide

anisaldehyde

triethylamine

→

p-methoxybenzaldehyde cyanohydrin

溶媒

ethyl alcohol

反応条件

後処理

1. 1
   workup.ALIQUOTIn situ sampling of the reaction mixture
2. 2
   その他the reaction
3. 3
   その他to quench
4. 4
   その他the reaction
5. 5
   ろ過tHE solution is filtered
6. 6
   その他used in the next step without further purification
7. 7
   その他Yield

実験手順

To 49 g (1 mole) of sodium cyanide and 136 g (1 mole) anisaldehyde in ethyl alcohol 800 ml), containing triethylamine (5 mol %, 5.1 g) is added HCl gas (1 mol, 36.5 g) over 30 minutes at 5°-10° C. The resulting slurry is stirred at that temperature for 6 hours. In situ sampling of the reaction mixture shows the reaction to be complete. Additional HCl (0.2 moles) is added to quench the reaction. tHE solution is filtered and used in the next step without further purification. Yield, ca. 80%.

出典